Screening methods typically fall into two categories: affinity screening, which scans library molecules for binders to isolated targets, and functional screening, which tests ligands on cells for a response. Typically, functional screening has low throughputs and often performed in microtitre plates.
The Orbit Peptide Display Platform facilitates the screening of millions of peptide hits in functional assays. Using a combination of our bead technology and microfluidics we have successfully identified peptide agonists targeting GPCRs and other cell surface proteins.
Using our microfluidics approach, a single species of peptide can be expressed off-bead and free to interact with a reporter cell in a self-contained droplet
Screen peptides in a cellular context to identify agonists, antagonists and other target-specific modulators
No more piles of 384 well plates. Our microfludic platform can screen millions of peptides in a single experiment.
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Stress-tested with GPCRs. We built the functional screening platform with difficult targets in mind. Recombinant target: not required.
