Scientific Collateral from Orbit Discovery

Read our scientific articles in peer-reviewed magazines, book chapters and conference posters


Combinatorial HLA-peptide bead libraries
for high throughput identification of CD8+
T cell specificity; Pan et al, 2014

This paper describes probing of cell surface targets using the Orbit method. Different T-cell populations were screened for binding to T-cell receptors and peptides with appropriate structures for each T-cell population were identified.

Linking genotype to phenotype on beads: high throughput selection of peptides with biological function; Huang et al, 2013

This paper describes the use of the Orbit method to identify peptides which bind to the HIV GP120 and which were then shown to inhibit HIV infection via CD4 binding in a cell-based assay. A 9aa peptide was identified with similar potency to an approved product.


Cyclic Peptide Design | Chapter 13
Peptide Display Technologies
by Anthony Pitt and Zeke Nims

With an increased interest in the use of peptides as therapeutics comes the need for strategies to allow for the discovery of novel hit candidates, in high-throughput manner, from highly complex peptide libraries. Early development of peptide therapeutics arose from the deployment of natural peptides and subsequent modification to enhance medicinal properties. Here, the  implementation of synthetic peptide libraries of low complexity was sufficient, but these low-diversity starting points are an obvious limitation to the discovery of novel peptides. This limitation is compounded by the almost unarguable desire to explore unnatural amino acid chemical space, moving away from the reliance upon natural peptides.

(Part of) Methods in Molecular Biology | Springer Protocols
ISBN 978-1-4939-9503-5 ISBN 978-1-4939-9504-2 (eBook)


Poster 2019 conferences

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