OD-2019-004 | Research Assistant – Cell-Free Expression System Development and Protein Purification

Location: Oxford

  • Job descriptionOpen or Close

    The position will hold a key role in the development of a cell-free translation system to be utilised in the Orbit peptide screening platform. The main responsibilities will be developing cell-free expression systems, purifying and charging tRNAs and producing recombinant proteins. In addition, you will assist the daily running of the lab and maintenance of the equipment.

  • Overview of the roleOpen or Close

    This role is critical to our success by helping to ensure and improve the performance of our cell-free translation system and to expand its utility in incorporation of non-natural amino acids in peptide libraries.

    You must be a highly organised, collaborative, detail-oriented scientist possessing knowledge and experience in molecular biology and biochemistry with an ability to produce work to a high standard. The position requires a MSc, preferably with an industry background. You will have the opportunity to be trained in other technologies, be a key member of the team and will benefit from an excellent remuneration package including share options.

  • Responsibilities/dutiesOpen or Close

    • Synthesise cell-free systems for in-house usage.

    • Produce recombinant proteins for the cell-free system.

    • Purify and charge tRNA.

    • Assist in optimising cell-free expression systems and help establish routine production procedures.

    • Troubleshoot equipment and methods within the process development of cell-free system.

    • QC of cell-free system.

    • Maintain best practice, quality standards and accurate record keeping.

    • Keep up to date with and support implementation of new technologies and protocols.

    • Communicate effectively with all members of the company and with collaborators.

    • Have focus on both short- and medium-term objectives.

    • Ensure laboratory records are complete, accurate and up to date.

    • Thrive in an environment of openness, teamwork and accountability.

    • Support general lab duties, e.g. reagent preparation, cleaning and stocking.

    Additionally, you will:

    • Write drafts of scientific reports for internal use and communication with partner companies.

    • Identify potentially platform improvements.

    • Present research to specialist and non-specialist audiences.

    • Ensure that your work in the department is conducted safely, and legally in accordance with the highest standards of data protections.

    • Adhere to the values of the company policies and practices.

  • RequirementsOpen or Close

    • MSc in molecular biology and biochemistry.

    • At least 2 years industry or academia working experience.

    • Experience with protein purification, PCR, Western blot and bacteria culture.

    • Capacity to execute tasks independently to achieve company goals on an established timeline.

    • Superb communication, organization, attention-to-details, multi-tasking, adaptability and teamwork skills.

    • Knowledge of, and appreciation for, laboratory safety procedures.

    • Enthusiasm to work in a dynamic research environment.

  • DesirableOpen or Close

    • Experience of working in production environment.

    • Experience with the use of AKTA system.

    • Hands-on experience in a variety of molecular biology and biochemistry techniques.


    Applicants should provide a full CV with a list of their publications to date, contact details for 2 referees and a cover letter describing their suitability for the position.

    Applications should be sent to

  Apply by email
  Download PDF of OD-2019-004


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